Active Ingredient: Ribavirin
Ribavirin is indicated in combination with other medicinal products for the treatment of chronic hepatitis C (CHC) for paediatric patients (children 3 years of age and older and adolescents) not previously treated and without liver decompensation.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
600 - 800 mg
From 300 To 400 mg 2 time(s) per day every day
No data are available in children below 3 years of age.
Dosing of ribavirin for children and adolescent patients is determined by the patient body weight. For example, the body weight dosing used in conjunction with interferon alfa-2b or peginterferon alfa-2b is shown in the table. Please refer to the corresponding SmPC of medicinal products used in combination with ribavirin as some combination regimens do not adhere to the ribavirin dosing guidance provided in the following table.
Ribavirin dose based on body weight when used in combination with interferon alfa-2b or peginterferon alfa-2b in paediatric patients:
| Patient weight (kg) | Daily ribavirin dose | Number of 200 mg capsules |
|---|---|---|
| 47-49 | 600 mg | 3 capsulesa |
| 50-65 | 800 mg | 4 capsulesb |
| >65 | Refer to adult dose recommendations | |
a 1 morning, 2 evening
b 2 morning, 2 evening
It should be administered orally with food.
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