Active Ingredient: Dobutamine
Dobutamine may also be used for detection of myocardial ischaemia and of viable myocardium within the scope of an echocardiographic examination (dobutamine stress echocardiography), if patients cannot undergo a period of exercise or if the exercise yields no information of value.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
5 - 50 ug per kg of body weight
From 5 To 50 ug per kg of body weight once every day
Administration in stress echocardiography is undertaken by gradually increasing dobutamine infusion.
The most frequently applied dosage scheme starts with 5 ยตg/kg/min Dobutamine increased every 3 minutes to 10, 20, 30, 40 ยตg/kg/min until a diagnostic endpoint is reached.
If no endpoint is reached atropine sulfate may be administered at 0.5 to 2 mg in divided doses of 0.25-0.5 mg at 1 minute intervals to increase the heart rate. Alternatively the infusion rate of dobutamine may be increased to 50 ยตg/kg/min.
For detection of myocardial ischaemia and of viable myocardium dobutamine may only be administered by a physician with sufficient experience in conducting cardiology stress tests. Continuous monitoring of all wall areas via echocardiography, and ECG as well as control of blood pressure is necessary.
Monitoring devices as well as emergency medicines must be available (e.g. defibrillator, I.V. beta-blockers, nitrates, etc.) and staff trained in the resuscitation procedure must be present.
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