Active Ingredient: Diroximel fumarate
For this indication, competent medicine agencies globally authorize below treatments:
Oral
462 - 924 mg
From 231 To 462 mg 2 time(s) per day every day
462 mg
924 mg
The starting dose is 231 mg twice a day. After 7 days, the dose should be increased to the recommended maintenance dose of 462 mg twice a day.
Temporary dose reductions to 231 mg twice a day may reduce the occurrence of flushing and gastrointestinal adverse reactions. Within 1 month, the recommended dose of 462 mg twice a day should be resumed.
If a patient misses a dose, a double dose should not be taken. The patient may take the missed dose only if they leave 4 hours between doses. Otherwise, the patient should wait until the next scheduled dose.
The diroximel fumarate capsule should be swallowed whole and intact. The capsules should not be crushed or chewed and the contents should not be sprinkled on food because the enteric-coating of the capsule contents prevents irritant effects on the gut.
It can be taken with or without food. For those patients who may experience flushing or gastrointestinal adverse reactions, taking with food may improve tolerability.
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