Leukaemic meningitis

Active Ingredient: Cytarabine

Indication for Cytarabine

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

Total daily dose not exceeding 100 mg

For:

Dosage regimens

Regimen A: Intravenous, 100 milligrams cytarabine, once daily.

Regimen B: Intraspinal, between 10 milligrams cytarabine per square meter of body surface and 30 milligrams cytarabine per square meter of body surface, 3 times weekly.

Detailed description

Therapy for established meningitis employs a wide variety of dose regimens but a recommended total daily dose not exceeding 100 mg, alternating with methotrexate (given either systemically or intrathecally) is recommended.

Active ingredient

Cytarabine

Cytarabine (ARA-C) is metabolised in vivo to ARA-CTP phosphorylated compound. This competitively inhibits DNA polymerase and may also inhibit certain acid kinase enzymes.

Read more about Cytarabine

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