Active Ingredient: Propranolol
Propranolol is indicated in the treatment of proliferating infantile haemangioma requiring systemic therapy:
It is to be initiated in infants aged 5 weeks to 5 months.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
1 - 3 mg per kg of body weight
From 0.5 To 1.5 mg per kg of body weight 2 time(s) per day every day for 180 day(s)
1 mg per kg of body weight
3 mg per kg of body weight
The posology is expressed in propranolol base.
The recommended starting dose is 1 mg/kg/day which is divided into two separate doses of 0.5 mg/kg.
It is recommended to increase the dose up to the therapeutic dose under medical supervision as follows: 1 mg/kg/day for 1 week, then 2 mg/kg/day for 1 week and then 3 mg/kg/day as a maintenance dose.
The therapeutic dose is 3 mg/kg/day, which is to be administered into 2 separate doses of 1.5 mg/kg, one in the morning and one in late afternoon, with a time interval of at least 9 hours between two intakes. Propranolol is to be given during or right after a feed to avoid the risk of hypoglycaemia.
If the child is not eating or is vomiting it is recommended to skip the dose.
In case the child spits up a dose or does not take all of the medicinal product no other dose should be given before the next scheduled dose.
During the titration phase, each dose increase must be managed and monitored by a physician in the same conditions as the administration of the initial dose. After the titration phase, the dose will be readjusted by the physician according to the changes in the child’s weight.
Clinical monitoring of the child condition, and dose readjustment, need to be performed at least monthly.
Propranolol should be administered for a 6-month period.
Discontinuation of treatment does not require a progressive decrease in the dose. In the minority of patients showing a relapse of symptoms after treatment discontinuation, treatment may be re-initiated under the same conditions with a satisfactory response.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.
