Active Ingredient: Prucalopride
Prucalopride is indicated for symptomatic treatment of chronic constipation in adults in whom laxatives fail to provide adequate relief.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
2 - 2 mg
From 2 To 2 mg once every day
2 mg once daily with or without food, at any time of the day.
Due to the specific mode of action of prucalopride (stimulation of propulsive motility), exceeding the daily dose of 2 mg is not expected to increase efficacy.
If the intake of once daily prucalopride is not effective after 4 weeks of treatment, the patient should be re-examined and the benefit of continuing treatment reconsidered.
The efficacy of prucalopride has been established in double-blind, placebo-controlled studies for up to 3 months. Efficacy beyond three months has not been demonstrated in placebo-controlled studies. In case of prolonged treatment, the benefit should be reassessed at regular intervals.
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