Active Ingredient: Propofol
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Intravenous, between 0.5 milligrams propofol per kilogram of body weight and 1 milligrams propofol per kilogram of body weight, over the duration of 1 to 5 minutes.
Regimen B: Intravenous, between 1.5 milligrams propofol per kilogram of body weight and 4.5 milligrams propofol per kilogram of body weight, over the duration of 1 hour.
To provide sedation during surgical and diagnostic procedures, doses and administration rates should be adjusted according to the clinical response. Most patients will require 0.5-1 mg propofol/kg bodyweight over 1 to 5 minutes for onset of sedation. Maintenance of sedation may be accomplished by titrating propofol 1% infusion to the desired level of sedation. Most patients will require 1.5-4.5 mg propofol/kg bodyweight/h. The infusion may be supplemented by bolus administration of 10-20 mg propofol (1-2 ml propofol 1%) if a rapid increase of the depth of sedation is required.
In patients older than 55 years and in patients of ASA grades III and IV lower doses of propofol 1% may be required and the rate of administration may need to be reduced.
For:
Intravenous, between 1 milligrams propofol per kilogram of body weight and 9 milligrams propofol per kilogram of body weight, over the duration of 1 hour.
Doses and administration rates should be adjusted according to the required depth of sedation and the clinical response. Most paediatric patients require 1-2 mg/kg bodyweight propofol for onset of sedation. Maintenance of sedation may be accomplished by titrating propofol 1% infusion to the desired level of sedation. Most patients require 1.5-9 mg/kg/h propofol. With propofol 1% the infusion may be supplemented by bolus administration of up to 1 mg/kg bodyweight if a rapid increase of depth of sedation is required.
In ASA III and IV patients lower doses may be required.
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