Active Ingredient: Ramucirumab
Ramucirumab, in combination with FOLFIRI (irinotecan, folinic acid, and 5-fluorouracil), is indicated for the treatment of adult patients with metastatic colorectal cancer (mCRC) with disease progression on or after prior therapy with bevacizumab, oxaliplatin and a fluoropyrimidine.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
8 - 8 mg per kg of body weight
From 8 To 8 mg per kg of body weight once every 15 day(s)
The recommended dose of ramucirumab is 8 mg/kg every 2 weeks administered by intravenous infusion, prior to FOLFIRI administration. Prior to chemotherapy, patients should have a complete blood count. Criteria to be met prior to FOLFIRI are provided in the following table.
Criteria to be met prior to FOLFIRI administration:
| Criteria | |
|---|---|
| Neutrophils | ≥1.5 × 109/l |
| Platelets | ≥100 × 109/l |
| Chemotherapy-related gastro-intestinal toxicity | ≤ Grade 1 (National Cancer Institute Common Terminology Criteria for Adverse Events [NCI CTCAE]) |
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