Prevention of influenza

Active Ingredient: Oseltamivir

Indication for Oseltamivir

Population group: only children (1 year - 12 years old)

Post-exposure prevention in individuals 1 year of age or older following contact with a clinically diagnosed influenza case when influenza virus is circulating in the community.

The appropriate use of oseltamivir for prevention of influenza should be determined on a case by case basis by the circumstances and the population requiring protection. In exceptional situations (e.g. in case of a mismatch between the circulating and vaccine virus strains, and a pandemic situation) seasonal prevention could be considered in individuals one year of age or older.

Oseltamivir is indicated for post-exposure prevention of influenza in infants less than 1 year of age during a pandemic influenza outbreak.

For this indication, competent medicine agencies globally authorize below treatments:

30-75 mg once daily

Route of admnistration

Oral

Defined daily dose

30 - 75 mg

Dosage regimen

From 30 To 75 mg once every day for 10 day(s)

Detailed description

Post-exposure prevention

The recommended post-exposure prevention dose is:

Body WeightRecommended dose for 10 days
10 kg to 15 kg30 mg once daily
>15 kg to 23 kg45 mg once daily
>23 kg to 40 kg60 mg once daily
>40 kg75 mg once daily

Prevention during an influenza epidemic in the community

Prevention during an influenza epidemic has not been studied in children below 12 years of age.

Active ingredient

Oseltamivir

Oseltamivir (oseltamivir carboxylate) is a selective inhibitor of influenza virus neuraminidase enzymes, which are glycoproteins found on the virion surface. Viral neuraminidase enzyme activity is important both for viral entry into uninfected cells and for the release of recently formed virus particles from infected cells, and for the further spread of infectious virus in the body.

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