HIV-1 infection

Active Ingredient: Indinavir

Indication for Indinavir

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Indinavir is indicated in combination with antiretroviral nucleoside analogues for the treatment of HIV-1 infected adults.

For this indication, competent medicine agencies globally authorize below treatments:

1500 mg/m² in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

1,500 - 1,500 mg per m² of body surface area (BSA)

Dosage regimen

From 500 To 500 mg per m² of body surface area (BSA) 3 time(s) per day every day

Detailed description

Children above the age of 4 years.

Dosage considerations

For optimal absorption, indinavir should be administered without food but with water 1 hour before or 2 hours after a meal. Alternatively, indinavir may be administered with a low-fat, light meal.

Active ingredient

Indinavir

Indinavir inhibits recombinant HIV-1 and HIV-2 protease with an approximate tenfold selectivity for HIV-1 over HIV-2 proteinase. Indinavir binds reversibly to the protease active site and inhibits competitively the enzyme, thereby preventing cleavage of the viral precursor polyproteins that occurs during maturation of the newly formed viral particle.

Read more about Indinavir

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