Eradication of Helicobacter pylori

Active Ingredient: Esomeprazole

Indication for Esomeprazole

Population group: only children (1 year - 12 years old)

Healing of Helicobacter pylori associated duodenal ulcer.

For this indication, competent medicine agencies globally authorize below treatments:

20 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

20 - 20 mg

Dosage regimen

From 10 To 10 mg 2 time(s) per day every day for 7 day(s)

Loading dose

20 mg

Detailed description

Children over 4 years of age

When selecting appropriate combination therapy, consideration should be given to official national, regional and local guidance regarding bacterial resistance, duration of treatment (most commonly 7 days but sometimes up to 14 days), and appropriate use of antibacterial agents. The treatment should be supervised by a specialist.

The posology recommendation is:

WeightPosology
<30 kgCombination with two antibiotics: esomeprazole 10 mg, amoxicillin 25 mg/kg body weight and clarithromycin 7.5 mg/kg body weight are all administered together twice daily for one week.
30-40 kgCombination with two antibiotics: esomeprazole 20 mg, amoxicillin 750 mg and clarithromycin 7.5 mg/kg body weight are all administered together twice daily for one week.
>40 kgCombination with two antibiotics: esomeprazole 20 mg, amoxicillin 1 g and clarithromycin 500 mg are all administered together twice daily for one week.

Active ingredient

Esomeprazole

Esomeprazole is the S-isomer of omeprazole and reduces gastric acid secretion through a specific targeted mechanism of action. Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H+ K+ -ATPase – the acid pump and inhibits both basal and stimulated acid secretion.

Read more about Esomeprazole

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