Active Ingredient: Ezetimibe
Ezetimibe co-administered with a statin, is indicated as adjunctive therapy to diet for use in patients with homozygous familial hypercholesterolaemia (HoFH). Patients may also receive adjunctive treatments (e.g. LDL apheresis).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 10 milligrams ezetimibe, once daily.
The patient should be on an appropriate lipid lowering diet and should continue on this diet during treatment with ezetimibe.
The recommended dose is one 10 mg daily. If as dose is missed, take the missed dose as soon as possible. Do not double the next dose.
When ezetimibe is added to a statin, either the indicated usual initial dose of that particular statin or the already established higher statin dose should be continued. In this setting, the dosage instructions for that particular statin should be consulted.
Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating ezetimibe.
In patients taking a bile acid sequestrant, administer ezetimibe at least 2 hours before or 4 hours after the bile acid sequestrant.
Ezetimibe can be administered at any time of the day, with or without food.
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