Active Ingredient: Ethanol
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, between 600 milligrams ethanol per kilogram of body weight and 800 milligrams ethanol per kilogram of body weight, one dose, over the duration of 30 minutes. Afterwards, intravenous, between 120 milligrams ethanol per kilogram of body weight and 138 milligrams ethanol per kilogram of body weight, once hourly.
A loading dose of 600–800mg/kg should be given. If used parenterally this should be in the form of 7.5ml/kg of a 10% infusion of Ethanol in 5% Glucose Solution for Infusion. The infusion should be given over 30 minutes preferably via a central venous catheter.
The standard maintenance dose, for an average patient is 120-138mg of 100% ethanol/kg/hr (1.38ml of 10% ethanol/kg/hr) by the IV route.
Blood monitoring should occur every 1-2hours until a concentration of 1-1.5g/L is reached and thereafter at 2-4hourly intervals. After the loading dose maintenance concentrations should be reduced dependant on the normal drinking habits of the patient and any other concomitant treatments.
Patients treated with Ethanol require close monitoring preferably in a critical care area because of the risk of CNS and respiratory depression.
| Amount Absolute (100%) Ethanol | Volume 5% Ethanol by IV Injection | Volume 10% Ethanol by IV Injection | |
|---|---|---|---|
| Loading Dose Over 30 minutes | 600-800mg/kg | 15ml/kg | 7.5ml/kg |
| Standard maintenance dose (average adult) | 120-138 mg/kg/hr | 2.76/ml/kg/hr | 1.38ml/kg/hr |
| Standard maintenance dose (drinker) | 184-196 mg/kg/hr | 3.92ml/kg/hr | 1.96ml/kg/hr |
| Maintenance dose during dialysis (average adult) | 240-268 mg/kg/hr | 5.36ml/kg/hr | 2.68ml/kg/hr |
| Maintenance dose during dialysis (drinker) | 308-326 mg/kg/hr | 6.52ml/kg/hr | 3.26ml/kg/hr |
Ethanol can be added to peritoneal dialysate at a concentration of 1-2g/L of dialysate.
For:
Intravenous, between 600 milligrams ethanol per kilogram of body weight and 800 milligrams ethanol per kilogram of body weight, one dose, over the duration of 30 minutes. Afterwards, intravenous, between 80 milligrams ethanol per kilogram of body weight and 83 milligrams ethanol per kilogram of body weight, once hourly.
A loading dose of 600–800mg/kg should be given. If used parenterally this should be in the form of 7.5ml/kg of a 10% infusion of Ethanol in 5% Glucose Solution for Infusion. The infusion should be given over 30 minutes preferably via a central venous catheter.
Blood monitoring should occur every 1-2hours until a concentration of 1-1.5g/L is reached and thereafter at 2-4hourly intervals. After the loading dose maintenance concentrations should be reduced dependant on the normal drinking habits of the patient and any other concomitant treatments.
Patients treated with Ethanol require close monitoring preferably in a critical care area because of the risk of CNS and respiratory depression.
| Amount Absolute (100%) Ethanol | Volume 5% Ethanol by IV Injection | Volume 10% Ethanol by IV Injection | |
|---|---|---|---|
| Loading Dose Over 30 minutes | 600-800mg/kg | 15ml/kg | 7.5ml/kg |
| Standard maintenance dose (non-drinker/child) | 80-83 mg/kg/hr | 1.66ml/kg/hr | 0.83ml/kg/hr |
| Maintenance dose during dialysis (non-drinker/child) | 200-213 mg/kg/hr | 4.26ml/kg/hr | 2.13ml/kg/hr |
Ethanol can be added to peritoneal dialysate at a concentration of 1-2g/L of dialysate.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.
