Sarcotopic scabies

Active Ingredient: Afoxolaner

Indication for Afoxolaner

For this indication, competent medicine agencies globally authorize below treatments:

2.7-7.0 mg/kg monthly

Dosage regimens

Oral, between 2.7 milligrams afoxolaner per kilogram of body weight and 7 milligrams afoxolaner per kilogram of body weight, once monthly.

Detailed description

The product should be administered at a dose of 2.7-6.9 mg/kg bodyweight in accordance with the following table:

Bodyweight of dog (kg) Strength and number of chewable tablets to be administered
afoxolaner 11 mg afoxolaner 28 mg afoxolaner 68 mg afoxolaner 136 mg
2–4 1   
>4–10  1  
>10–25  1 
>25–50   1

For dogs above 50 kg bodyweight, use an appropriate combination of chewable tablets of different/same strengths. The tablets should not be divided.

Dosage considerations

The tablets are chewable and palatable to most dogs. If the dog does not accept the tablets directly they may be administered with food.

Active ingredient

Afoxolaner

Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family. Afoxolaner acts at ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. The selective toxicity of afoxolaner between insect/acarines and mammals may be inferred by the differential sensitivity of the insect/acarinesโ€™ GABA receptors versus mammalian receptors. Afoxolaner is active against adult fleas as well as several tick species such as Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Rhipicephalus sanguineus, Amblyomma americanum and Haemaphysalis longicornis.

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