Primary hypercholesterolaemia

Active Ingredient: Bempedoic acid

Indication for Bempedoic acid

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Bempedoic acid is indicated in adults with primary hypercholesterolaemia (heterozygous familial and nonfamilial) as an adjunct to diet:

  • in combination with a statin or statin with other lipid-lowering therapies in patients unable to reach LDL-C goals with the maximum tolerated dose of a statin or,
  • alone or in combination with other lipid-lowering therapies in patients who are statin-intolerant, or for whom a statin is contraindicated.

For this indication, competent medicine agencies globally authorize below treatments:

180 mg once daily

For:

Dosage regimens

Oral, 180 milligrams bempedoic acid, once daily.

Detailed description

The recommended dose of bempedoic acid is 180 mg once daily.

Concomitant simvastatin therapy

When bempedoic acid is coadministered with simvastatin, simvastatin dose should be limited to 20 mg daily (or 40 mg daily for patients with severe hypercholesterolaemia and high risk for cardiovascular complications, who have not achieved their treatment goals on lower doses and when the benefits are expected to outweigh the potential risks).

Dosage considerations

It should be taken orally with or without food.

Active ingredient

Bempedoic acid

Bempedoic acid is an adenosine triphosphate citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibition of cholesterol synthesis in the liver. Bempedoic acid requires coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1) to ETC-1002-CoA. Inhibition of ACL by ETC-1002-CoA results in decreased cholesterol synthesis in the liver and lowers LDL-C in blood via upregulation of low-density lipoprotein receptors. Additionally, inhibition of ACL by ETC-1002-CoA results in concomitant suppression of hepatic fatty acid biosynthesis.

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