Active Ingredient: Corifollitropin alfa
Corifollitropin alfa is indicated for Controlled Ovarian Stimulation (COS) in combination with a Gonadotropin Releasing Hormone (GnRH) antagonist for the development of multiple follicles in women participating in an Assisted Reproductive Technology (ART) program.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous
100 - 150 ug
From 100 To 150 ug once every day
In the treatment of women of reproductive age, the dose of corifollitropin alfa is based on weight and age.
Women older than 36 years of age who weighed less than 50 kilograms were not studied.
| Body Weight | ||||
|---|---|---|---|---|
| Less than 50 kg | 50-60 kg | More than 60 kg | ||
| Age | 36 years or younger | 100 micrograms | 100 micrograms | 150 micrograms |
| Older than 36 years | Not studied | 150 micrograms | 150 micrograms | |
The recommended doses of corifollitropin alfa have only been established in a treatment cycle with a GnRH antagonist that was administered from stimulation day 5 or day 6 onwards.
Stimulation day 1: corifollitropin alfa should be administered as a single subcutaneous injection, preferably in the abdominal wall, during the early follicular phase of the menstrual cycle.
Stimulation day 5 or 6: Treatment with a GnRH antagonist should be started on stimulation day 5 or day 6 depending on the ovarian response, i.e. the number and size of growing follicles. The concurrent determination of serum oestradiol levels may also be useful. The GnRH antagonist is used to prevent premature Luteinising Hormone (LH) surges.
Stimulation day 8: Seven days after the injection with corifollitropin alfa on stimulation day 1, COS treatment may be continued with daily injections of (recombinant) Follicle Stimulating Hormone [(rec)FSH] until the criterion for triggering final oocyte maturation (3 follicles ≥17 mm) has been reached. The daily dose of (rec)FSH may depend on the ovarian response. In normal responders a daily dose of 150 IU (rec)FSH is advised. Administration of (rec)FSH on the day of human Chorionic Gonadotropin (hCG) administration can be omitted, depending on the ovarian response. In general, adequate follicular development is achieved on average by the ninth day of treatment (range 6 to 18 days).
As soon as three follicles 17 mm are observed, a single injection of 5,000 up to 10,000 IU hCG is administered the same day or the day thereafter to induce final oocyte maturation.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.
