Advanced neuroblastoma

Active Ingredient: Melphalan

Indication for Melphalan

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

100-240 mg/m² body surface area once

Route of admnistration

Intravenous

Defined daily dose

100 - 240 mg per m² of body surface area (BSA)

Dosage regimen

From 100 To 240 mg per m² of body surface area (BSA) once every day for 1 day(s)

Detailed description

Doses of between 100 and 240 mg/m² body surface area (sometimes divided equally over 3 consecutive days) together with haematopoietic stem cell rescue, have been used either alone or in combination with radiotherapy and/or other cytotoxic drugs.

Active ingredient

Melphalan

Melphalan is a bifunctional alkylating agent. Formation of carbonium intermediates from each of the two bis-2-chloroethyl groups enables alkylation through covalent binding with the 7-nitrogen of guanine on DNA, cross-linking the two DNA strands and thereby preventing cell replication.

Read more about Melphalan

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