Active Ingredient: Solifenacin
For this indication, competent medicine agencies globally authorize below treatments:
Oral
1.5 - 10 mg
From 1.5 To 10 mg once every day
1.5 mg
The recommended dose of solifenacin is determined based on patient weight. Treatment should be initiated at the recommended starting dose. Thereafter, the dose may be increased to the lowest effective dose. The maximum dose should not be exceeded. During long-term therapy, patients should be periodically evaluated for treatment continuation and for potential dose adjustment, at least annually or more frequently if indicated.
| Weight range (kg) | Starting dose (ml)§1 | Maximum dose (ml)§2 |
|---|---|---|
| 9 to 15 | 2 | 4 |
| >15 to 30 | 3 | 5 |
| >30 to 45 | 3 | 6 |
| >45 to 60 | 4 | 8 |
| >60 | 5 | 10 |
§ The oral suspension formulation of Vesicare has a concentration of 1 mg/ml.
1 Equivalent to steady-state exposure after a 5 mg daily dose in adults.
2 Equivalent to steady-state exposure after a 10 mg daily dose in adults.
It should be taken orally followed by a glass of water. It should not be ingested together with food and/or other drinks. This ingestion with food and/or drinks may cause a release of solifenacin in the mouth resulting in a bitter taste and a feeling of numbness in the mouth.
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