Falciparum malaria

Active Ingredient: Quinine

Indication for Quinine

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Treatment of falciparum (malignant tertian) malaria.

For this indication, competent medicine agencies globally authorize below treatments:

1,800 mg in 3 divided doses daily

Route of admnistration

Oral

Defined daily dose

1,800 - 1,800 mg

Dosage regimen

From 600 To 600 mg 3 time(s) per day every day for 7 day(s)

Detailed description

Adults (including elderly) and children aged 12 years and over: 600mg every eight hours for 7 days. The dose may depend upon the size of the patient, severity of infection, and evidence of renal or liver disease (when the intervals should be increased), due to a prolonged half-life of the drug.

If quinine resistance is known or suspected on completion of the course additional treatment may be given. This may be one of the following:

  • doxycycline 200mg daily (as a single dose or in 2 divided doses) for at least 7 days.
  • clindamycin 300mg four times daily for 5 days.

Active ingredient

Quinine

Quinine is a cinchona alkaloid and a 4-methanolquinoline antimalarial agent which is a rapidly acting blood schizontocide with activity against Plasmodium falciparum, P vivax, P ovale and P malariae. It is active against the gametocytes of P malariae and P vivax, but not against mature gametocytes of P falciparum.

Read more about Quinine

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