Active Ingredient: Primidone
For this indication, competent medicine agencies globally authorize below treatments:
Oral
50 - 750 mg
From 25 To 375 mg 2 time(s) per day every day
Initially a dose of 50 mg daily should be introduced. The daily dose should be increased gradually over a 2 to 3 week period until remission of symptoms or the highest dose tolerated up to a maximum of 750 mg daily.
Patients with essential tremor who have not previously been exposed to anticonvulsants, or other drugs known to induce increased hepatic enzyme activity, may experience acute symptoms of intolerance to primidone, frequently characterised by vertigo, unsteadiness and nausea. It is, therefore, essential to start such patients at a low dosage (initially 50 mg daily) increasing very slowly up to the maximum tolerated dose or that which produces remission of tremor (up to 750 mg daily).
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