Active Ingredient: Perindopril
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 2.5 milligrams perindopril, once daily at morning, over the duration of 2 weeks. Afterwards, oral, between 2.5 milligrams perindopril and 5 milligrams perindopril, once daily at morning, over the duration of 2 weeks.
It is recommended that perindopril, generally associated with a non-potassium-sparing diuretic and/or digoxin and/or a beta-blocker, be introduced under close medical supervision with a recommended starting dose of 2.5 mg taken in the morning. This dose may be increased after 2 weeks to 5 mg once daily if tolerated. The dose adjustment should be based on the clinical response of the individual patient.
In severe heart failure and in other patients considered to be at high risk (patients with impaired renal function and a tendency to have electrolyte disturbances, patients receiving simultaneous treatment with diuretics and/or treatment with vasodilating agents), treatment should be initiated under careful supervision.
Patients at high risk of symptomatic hypotension e.g. patients with salt depletion with or without hyponatraemia, patients with hypovolaemia or patients who have been receiving vigorous diuretic therapy should have these conditions corrected, if possible, prior to therapy with perindopril. Blood pressure, renal function and serum potassium should be monitored closely, both before and during treatment with perindopril.
It is recommended to be taken once daily in the morning before a meal.
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