Active Ingredient: Somatropin
In chronic renal insufficiency, renal function should be below 50 percent of normal before institution of therapy. To verify growth disturbance, growth should be followed for a year preceding institution of therapy. During this period, conservative treatment for renal insufficiency (which includes control of acidosis, hyperparathyroidism and nutritional status) should have been established and should be maintained during treatment. The treatment should be discontinued at renal transplantation.
To date, no data on final height in patients with chronic renal insufficiency treated with somatropin are available.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous
45 - 50 ug per kg of body weight
From 45 To 50 ug per kg of body weight once every day
A dose of 0.045-0.050 mg/kg body weight per day is recommended. Higher doses can be needed if growth velocity is too low. A dose correction can be needed after six months of treatment.
The injection should be given subcutaneously and the site varied to prevent lipoatrophy.
For:
Subcutaneous
1.4 - 1.4 mg per m² of body surface area (BSA)
From 1.4 To 1.4 mg per m² of body surface area (BSA) once every day
A dose of 1.4 mg/m² body surface area per day is recommended. Higher doses can be needed if growth velocity is too low. A dose correction can be needed after six months of treatment.
The injection should be given subcutaneously and the site varied to prevent lipoatrophy.
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