Post-operative nausea and vomiting (PONV)

Active Ingredient: Granisetron

Indication for Granisetron

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

10-40 ยตg/kg in 1-4 divided doses

Route of admnistration

Intravenous

Defined daily dose

10 - 40 ug per kg of body weight

Dosage regimen

From 2.5 To 10 ug per kg of body weight 4 time(s) per day every day

Detailed description

A dose of 10 ยตg/kg of granisetron should be administered by slow intravenous injection. The maximum dose of granisetron to be administered over 24 hours should not exceed 3 mg.

For the prevention of PONV, administration should be completed prior to induction of anaesthesia.

Dosage considerations

It should be administered either as a slow intravenous injection or as a diluted intravenous infusion 5 minutes prior to the start of chemotherapy or radiotherapy.

1-3 mg in 1-3 divided doses

Route of admnistration

Intravenous

Defined daily dose

1 - 3 mg

Dosage regimen

From 0.333 To 1 mg 3 time(s) per day every day

Detailed description

A dose of 1 mg of granisetron should be administered by slow intravenous injection. The maximum dose of granisetron to be administered over 24 hours should not exceed 3 mg.

For the prevention of PONV, administration should be completed prior to induction of anaesthesia.

Dosage considerations

It should be administered either as a slow intravenous injection or as a diluted intravenous infusion 5 minutes prior to the start of chemotherapy or radiotherapy.

Active ingredient

Granisetron

Granisetron is a potent anti-emetic and highly selective antagonist of 5-hydroxytryptamine (5HT3 receptors). Pharmacological studies have demonstrated that granisetron is effective against nausea and vomiting as a result of cytostatic therapy.

Read more about Granisetron

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