Stable angina pectoris

Active Ingredient: Nicorandil

Indication for Nicorandil

Population group: only adults (18 years old or older)

Nicorandil is indicated in adults for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled or have a contraindication or intolerance to first-line antianginal therapies (such as beta-blockers and/or calcium antagonists).

For this indication, competent medicine agencies globally authorize below treatments:

10-40 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

10 - 40 mg

Dosage regimen

From 5 To 20 mg 2 time(s) per day every day

Detailed description

The usual therapeutic range is 10 to 20 mg twice daily. The usual starting dose is 10 mg twice daily (bid), in the morning and in the evening preferably. It is recommended that the dose be titrated upwards in accordance with the patient’s needs, response and tolerance up to 40 mg twice daily, if necessary. A lower starting dose of 5 mg twice daily may be used in patients particularly prone to headache.

Dosage considerations

Administration is independent of food intake.

Active ingredient

Nicorandil

Nicorandil is a derivative of the niacinamide that is structurally combined with an organic nitrate. It provides a dual mode of action leading to relaxation of vascular smooth muscle. Nicorandil is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase. Nicorandil has a direct effect on coronary arteries without leading to a steal phenomenon. The overall action improves blood flow to post-stenotic regions and the oxygen balance in the myocardium.

Read more about Nicorandil

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