Active Ingredient: Lanreotide
The treatment of individuals with acromegaly when the circulating levels of Growth Hormone (GH) and/or Insulin-like Growth Factor-1 (IGF-1) remain abnormal after surgery and/or radiotherapy, or in patients who otherwise require medical treatment. The goal of treatment in acromegaly is to reduce GH and IGF-1 levels and where possible to normalise these values.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous
60 - 120 mg
From 60 To 120 mg once every 28 day(s)
The recommended starting dose is 60 mg to 120 mg administered every 28 days. The dose should be individualised according to the response of the patient (as judged by a reduction in symptoms and/or a reduction in GH and/or IGF-1 levels).
For patients in whom clinical symptoms and biochemical parameters are not adequately controlled (GH concentrations still above 2.5 ng/ml (approximately 5 mU/L) or IGF-1 greater than (age matched) normal), the dose of lanreotide may be increased to a maximum of 120 mg at 28 day intervals.
Patients well controlled on a somatostatin analogue can alternatively be treated with lanreotide 120 mg every 42-56 days (6 to 8 weeks).
Long term monitoring of symptoms, GH and IGF-1 levels should be routinely carried out in all patients.
Deep subcutaneous injection in the superior external quadrant of the buttock or in the upper outer thigh. In case of self-injection the injection should be given in the upper outer thigh.
Regardless of the injection site, the skin should not be folded and the needle should be inserted rapidly and to its full length, perpendicularly to the skin. The injection site should alternate between the right and left side.
For:
Intramuscular
30 - 30 mg
From 30 To 30 mg once every 14 day(s)
Initially, one intramuscular injection should be given every 14 days.
The frequency of subsequent injections may be varied in accordance with the individual patient’s response (as judged by a reduction in symptoms and/or a reduction in GH and/or IGF-1 levels) such that injections can be given every 7 to 10 days as necessary.
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