Treatment and prevention of nocturnal leg cramps

Active Ingredient: Quinine

Indication for Quinine

Population group: only adults (18 years old or older)

Treatment and prevention of nocturnal leg cramps in adults and the elderly, when cramps cause regular disruption of sleep.

For this indication, competent medicine agencies globally authorize below treatments:

200-300 mg once daily

Route of admnistration

Oral

Defined daily dose

200 - 300 mg

Dosage regimen

From 200 To 300 mg once every day

Detailed description

The recommended dose is 200mg at bedtime. The maximum dose is 300mg.

A reduction in frequency of leg cramps may take up to 4 weeks to become apparent. Patients should be monitored closely during the early stages of treatment for adverse effects. After an initial trial of 4 weeks, treatment should be stopped if there is no benefit. Treatment should be interrupted at approximately three monthly intervals to assess the need for continuation of treatment with quinine.

Active ingredient

Quinine

Quinine is a cinchona alkaloid and a 4-methanolquinoline antimalarial agent which is a rapidly acting blood schizontocide with activity against Plasmodium falciparum, P vivax, P ovale and P malariae. It is active against the gametocytes of P malariae and P vivax, but not against mature gametocytes of P falciparum.

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