Active Ingredient: Colesevelam
Colesevelam co-administered with a 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statin) is indicated as adjunctive therapy to diet to provide an additive reduction in low-density lipoprotein cholesterol (LDL-C) levels in adult patients with primary hypercholesterolaemia who are not adequately controlled with a statin alone.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
2,500 - 4,375 mg
From 1,250 To 2,187.5 mg 2 time(s) per day every day
The recommended dose of colesevelam for combination with a statin with or without ezetimibe is 2500-3750 mg per day. The maximum recommended dose is 3750 mg per day taken as 1875 mg twice per day with meals or 3750 mg taken once per day with a meal. Clinical trials have shown that colesevelam and statins can be co-administered or dosed apart, and that colesevelam and ezetimibe can be co- administered or dosed apart.
The recommended starting dose of colesevelam is 3750 mg per day taken as 1875 mg twice per day with meals or 3750 mg once per day with a meal. The maximum recommended dose is 4375 mg per day.
During therapy, the cholesterol-lowering diet should be continued, and serum total-C, LDL-C and triglyceride levels should be determined periodically during treatment to confirm favourable initial and adequate long-term responses.
When a drug interaction cannot be excluded with a concomitant medicinal product for which minor variations in the therapeutic level would be clinically important, or where no clinical data are available on co-administration, colesevelam should be administered at least four hours before or at least four hours after the concomitant medication in order to minimize the risk of reduced absorption of the concomitant medication.
Colesevelam tablets should be taken orally with a meal and liquid.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.
