Active Ingredient: Canagliflozin
Canagliflozin is indicated for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise:
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, between 100 milligrams canagliflozin and 300 milligrams canagliflozin, once daily -10 minutes before breakfast.
The recommended starting dose of canagliflozin is 100 mg once daily. In patients tolerating canagliflozin 100 mg once daily who have an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m² or CrCl ≥60 mL/min and need tighter glycaemic control, the dose can be increased to 300 mg once daily orally.
Care should be taken when increasing the dose in patients ≥75 years of age, patients with known cardiovascular disease, or other patients for whom the initial canagliflozin-induced diuresis poses a risk. In patients with evidence of volume depletion, correcting this condition prior to initiation of canagliflozin is recommended.
When canagliflozin is used as add-on therapy with insulin or an insulin secretagogue (e.g. sulphonylurea), a lower dose of insulin or the insulin secretagogue may be considered to reduce the risk of hypoglycaemia.
It should be taken orally once a day, preferably before the first meal of the day.
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