Active Ingredient: Micafungin
Treatment of oesophageal candidiasis in patients for whom intravenous therapy is appropriate.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
150 - 150 mg
From 150 To 150 mg once every day
Specimens for fungal culture and other relevant laboratory studies (including histopathology) should be obtained prior to therapy to isolate and identify causative organism(s). Therapy may be instituted before the results of the cultures and other laboratory studies are known. However, once these results become available, antifungal therapy should be adjusted accordingly.
The dose regimen of micafungin depends on the body weight of the patient as given in the following table.
Use in adults, adolescents ≥16 years of age and elderly:
| Indication | Body weight >40 kg | Body weight ≤40 kg |
|---|---|---|
| Treatment of oesophageal candidiasis | 150 mg/day | 3 mg/kg/day |
* If the patient’s response is inadequate, e.g. persistence of cultures or if clinical condition does not improve, the dose may be increased to 200 mg/day in patients weighing >40 kg or 4 mg/kg/day in patients ≤ 40 kg.
Micafungin should be administered for at least one week after resolution of clinical signs and symptoms.
After reconstitution and dilution, the solution should be administered by intravenous infusion over approximately 1 hour.
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