Active Ingredient: Dupilumab
Dupixent is indicated for the treatment of adults with moderate-to-severe prurigo nodularis (PN) who are candidates for systemic therapy.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous, 600 milligrams dupilumab, one dose, over the duration of 2 weeks. Afterwards, subcutaneous, 300 milligrams dupilumab, once every 2 weeks.
The recommended dose of dupilumab for adult patients is an initial dose of 600 mg, followed by 300 mg given every other week. Dupilumab can be used with or without topical corticosteroids.
PN clinical trial data are available for patients treated up to 24 weeks. Consideration should be given to discontinuing treatment in patients who have shown no response after 24 weeks of treatment for PN.
If a weekly dose is missed, administer the dose as soon as possible, starting a new schedule based on this date.
If an every other week dose is missed, administer the injection within 7 days from the missed dose and then resume the patient’s original schedule. If the missed dose is not administered within 7 days, wait until the next dose on the original schedule.
Dupilumab is administered by subcutaneous injection into the thigh or abdomen, except for the 5 cm around the navel. If somebody else administers the injection, the upper arm can also be used.
It is recommended to rotate the injection site with each injection. Dupilumab should not be injected into skin that is tender, damaged or has bruises or scars.
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