Severe eosinophilic asthma

Active Ingredient: Reslizumab

Indication for Reslizumab

Population group: only adults (18 - 65 years old)

Reslizumab is indicated as add-on therapy in adult patients with severe eosinophilic asthma inadequately controlled despite high-dose inhaled corticosteroids plus another medicinal product for maintenance treatment.

For this indication, competent medicine agencies globally authorize below treatments:

3 mg/kg once every 4 weeks

Route of admnistration

Intravenous

Defined daily dose

3 mg per kg of body weight

Dosage regimen

3 mg per kg of body weight once every 28 day(s)

Detailed description

Reslizumab is given as intravenous infusion once every four weeks.

The recommended dose is 3 mg/kg body weight.

Treatment duration

Reslizumab is intended for long-term treatment.

A decision to continue the therapy should be made at least annually based on disease severity and level of exacerbation control.

Missed dose

If a reslizumab infusion is missed on the planned date, dosing should resume as soon as possible on the indicated dose and regimen. A double dose must not be administered to make up for a missed dose.

Dosage considerations

It should be administered as a 20-50-minute intravenous infusion.

Active ingredient

Reslizumab

Reslizumab is a humanised monoclonal antibody (IgG4, Îș) against the human interleukin-5 (IL-5). Reslizumab binds specifically to IL-5 and interferes with IL-5 binding to its cell-surface receptor. IL-5 is a key cytokine responsible for the differentiation, maturation, recruitment and activation of human eosinophils. Reslizumab binds human IL-5 with picomolar affinity blocking its biological function; consequently survival and activity of eosinophils are reduced.

Read more about Reslizumab

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