Active Ingredient: Telbivudine
Telbivudine is indicated for the treatment of chronic hepatitis B in adult patients with compensated liver disease and evidence of viral replication, persistently elevated serum alanine aminotransferase (ALT) levels and histological evidence of active inflammation and/or fibrosis.
Initiation of telbivudine treatment should only be considered when the use of an alternative antiviral agent with a higher genetic barrier to resistance is not available or appropriate.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
600 - 600 mg
From 600 To 600 mg once every day
The recommended dose of telbivudine is 600 mg once daily.
On-treatment response at week 24 has been shown to be predictive of longer-term response. HBV DNA levels should be monitored at 24 weeks of treatment to assure complete viral suppression (HBV DNA less than 300 copies/ml). For patients with detectable HBV DNA after 24 weeks of therapy, treatment modification should be considered.
HBV DNA should be monitored every 6 months to assure continued response. If patients test positive for HBV DNA at any time after their initial response, treatment modification should be considered. Optimal therapy should be guided by resistance testing.
The optimal treatment duration is unknown. Treatment discontinuation should be considered as follows:
If a dose is missed, the patient may take the missed dose only up to 4 hours prior to the next scheduled dose. The next dose should be taken at the usual time.
It is to be taken orally, with or without food.
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