Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR)-activating mutations

Active Ingredient: Dacomitinib

Indication for Dacomitinib

Population group: only adults (18 years old or older)

Dacomitinib, as monotherapy, is indicated for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR)-activating mutations.

For this indication, competent medicine agencies globally authorize below treatments:

45 mg once a day

Route of admnistration

Oral

Defined daily dose

45 - 45 mg

Dosage regimen

From 45 To 45 mg once every day

Detailed description

The recommended dose of dacomitinib is 45 mg taken orally once daily, until disease progression or unacceptable toxicity occurs.

Patients should be encouraged to take their dose at approximately the same time each day. If the patient vomits or misses a dose, an additional dose should not be taken and the next prescribed dose should be taken at the usual time the next day.

Dosage considerations

It may be taken orally with or without food, at about the same time each day.

Active ingredient

Dacomitinib

Dacomitinib is a pan-human epidermal growth factor receptor (HER) (EGFR/HER1, HER2, and HER4) inhibitor, with activity against mutated EGFR with deletions in exon 19 or the L858R substitution in exon 21. Dacomitinib binds selectively and irreversibly to its HER family targets thereby providing prolonged inhibition.

Read more about Dacomitinib

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