Migraine

Active Ingredient: Propranolol

Indication for Propranolol

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

80-240 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

80 - 240 mg

Dosage regimen

From 40 To 120 mg 2 time(s) per day every day

Loading dose

80 mg

Detailed description

Initially 40 mg two or three times daily, increasing by the same amount at weekly intervals according to response. An adequate response in migraine and essential tremor is usually seen in the range 80-160 mg daily, and in angina 120-240 mg daily.

Active ingredient

Propranolol

Propranolol is a competitive antagonist at both beta, and beta2-adrenoceptor, but has membrane stabilising activity at concentrations exceeding 1-3mg/litre, though such concentrations are rarely achieved during oral therapy. Competitive beta-blockade has been demonstrated in man by a parallel shift to the right in the dose-heart rate response curve to beta-agonists such as isoprenaline.

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