Active Ingredient: Vutrisiran
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous, 25 milligrams vutrisiran, once every 90 days.
The recommended dose is 25 mg administered via subcutaneous injection once every 3 months.
Vitamin A supplementation at approximately, but not exceeding, 2500 IU to 3000 IU vitamin A per day is advised for patients treated with vutrisiran.
The decision to continue treatment in those patients whose disease progresses to stage 3 polyneuropathy should be taken at the discretion of the physician based on the overall benefit and risk assessment.
If a dose is missed, vutrisiran should be administered as soon as possible. Dosing should be resumed every 3 months, from the most recently administered dose.
No dose adjustment is required in patients ≥65 years of age.
The subcutaneous injection should be administered into one of the following sites: the abdomen, thighs, or upper arms. It should not be injected into scar tissue or areas that are reddened, inflamed, or swollen.
If injecting into the abdomen, the area around the navel should be avoided.
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