Active Ingredient: Guselkumab
Guselkumab, alone or in combination with methotrexate (MTX), is indicated for the treatment of active psoriatic arthritis in adult patients who have had an inadequate response or who have been intolerant to a prior disease-modifying antirheumatic drug (DMARD) therapy.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous, 100 milligrams guselkumab, once every 4 weeks, 2 doses in total. Afterwards, subcutaneous, 100 milligrams guselkumab, once every 8 weeks.
The recommended dose is 100 mg by subcutaneous injection at weeks 0 and 4, followed by a maintenance dose every 8 weeks. For patients at high risk for joint damage according to clinical judgement, a dose of 100 mg every 4 weeks (q4w) may be considered.
Consideration should be given to discontinuing treatment in patients who have shown no response after 24 weeks of treatment.
No dose adjustment is required.
There is limited information in subjects aged ≥65 years and very limited information in subjects aged ≥75 years.
Subcutaneous use. If possible, areas of the skin that show psoriasis should be avoided as injection sites.
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