Active Ingredient: Brexpiprazole
Brexpiprazole is indicated for the treatment of schizophrenia in adult patients.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
1 - 4 mg
From 1 To 4 mg once every day
The recommended starting dose for brexpiprazole is 1 mg once daily on days 1 to 4.
The recommended target dose range is 2 mg to 4 mg once daily.
Based on the patient’s clinical response and tolerability the brexpiprazole dose can be titrated to 2 mg once daily on day 5 through day 7 and then to 4 mg on day 8.
The maximum recommended daily dose is 4 mg.
When switching from other antipsychotics to brexpiprazole gradual cross-titration should be considered, with gradual discontinuation of the previous treatment while brexpiprazole treatment is initiated.
When switching to other antipsychotics from brexpiprazole, no gradual cross-titration is needed, the new antipsychotic should be initiated in its lowest dose while brexpiprazole is discontinued. It should be considered that plasma concentration of brexpiprazole will decline gradually and will be completely washed out in 1 to 2 weeks.
It can be taken with or without food.
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