Active Ingredient: Brexpiprazole
Brexpiprazole is indicated for the treatment of schizophrenia in adults and adolescents aged 13 years and older.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 1 milligrams brexpiprazole, once daily, over the duration of 4 days. Afterwards, oral, 2 milligrams brexpiprazole, once daily, over the duration of 3 days. Afterwards, oral, 4 milligrams brexpiprazole, once daily.
The recommended starting dose for brexpiprazole is 1 mg once daily on days 1 to 4.
The recommended target dose range is 2 mg to 4 mg once daily.
Based on the patient’s clinical response and tolerability the brexpiprazole dose can be titrated to 2 mg once daily on day 5 through day 7 and then to 4 mg on day 8.
The maximum recommended daily dose is 4 mg.
When switching from other antipsychotics to brexpiprazole, gradual cross-titration should be considered, with gradual discontinuation of the previous treatment while brexpiprazole treatment is initiated.
When switching to other antipsychotics from brexpiprazole, no gradual cross-titration is needed. The new antipsychotic should be initiated in its lowest dose while brexpiprazole is discontinued. It should be considered that plasma concentration of brexpiprazole will decline gradually and will be completely washed out in 1 to 2 weeks.
For:
In case that patient age in years is ≥ 13, oral, 0.5 milligrams brexpiprazole, once daily, over the duration of 4 days. Afterwards, in case that patient age in years is ≥ 13, oral, 1 milligrams brexpiprazole, once daily, over the duration of 3 days. Afterwards, in case that patient age in years is ≥ 13, oral, 2 milligrams brexpiprazole, once daily. The maximum allowed total dose is 4 milligrams brexpiprazole daily.
The recommended starting dose for brexpiprazole is 0.5 mg once daily on days 1 to 4.
The brexpiprazole dose should be titrated to 1 mg once daily on day 5 through day 7 and then to 2 mg on day 8. Weekly dose increases can be made in 1 mg increments based on clinical response and tolerability.
The recommended target dose range is 2 mg to 4 mg once daily. The maximum recommended daily dose is 4 mg.
When switching from other antipsychotics to brexpiprazole, gradual cross-titration should be considered, with gradual discontinuation of the previous treatment while brexpiprazole treatment is initiated.
When switching to other antipsychotics from brexpiprazole, no gradual cross-titration is needed. The new antipsychotic should be initiated in its lowest dose while brexpiprazole is discontinued. It should be considered that plasma concentration of brexpiprazole will decline gradually and will be completely washed out in 1 to 2 weeks.
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