Active Ingredient: Ustekinumab
Ustekinumab is indicated for the treatment of moderate to severe plaque psoriasis in children and adolescent patients from the age of 6 years and older, who are inadequately controlled by, or are intolerant to, other systemic therapies or phototherapies.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: In case that patient weight is ≤ 60 kg, subcutaneous, 0.75 milligrams ustekinumab per kilogram of body weight, once every 4 weeks, 2 doses in total. Afterwards, in case that patient weight is ≤ 60 kg, subcutaneous, 0.75 milligrams ustekinumab per kilogram of body weight, once every 12 weeks.
Regimen B: In case that patient weight is ≥ 60 kg and patient weight is ≤ 100 kg, subcutaneous, 45 milligrams ustekinumab, once every 4 weeks, 2 doses in total. Afterwards, in case that patient weight is ≥ 60 kg and patient weight is ≤ 100 kg, subcutaneous, 45 milligrams ustekinumab, once every 12 weeks.
Regimen C: In case that patient weight is ≥ 100 kg, subcutaneous, 90 milligrams ustekinumab, once every 4 weeks, 2 doses in total. Afterwards, in case that patient weight is ≥ 100 kg, subcutaneous, 90 milligrams ustekinumab, once every 12 weeks.
The recommended dose of ustekinumab based on body weight is shown below.
Ustekinumab should be administered at Weeks 0 and 4, then every 12 weeks thereafter.
Recommended dose of ustekinumab for paediatric psoriasis:
| Body weight at the time of dosing | Recommended Dose |
|---|---|
| <60 kg | 0.75 mg/kg |
| ≥60 - ≤100 kg | 45 mg |
| >100 kg | 90 mg |
Consideration should be given to discontinuing treatment in patients who have shown no response up to 28 weeks of treatment.
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