Active Ingredient: Ceftriaxone
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
50 - 100 mg per kg of body weight
From 50 To 100 mg per kg of body weight once every day
Neonates 0-14 days: The generally recommended dose is 50 mg/kg once daily for 10-14 days. The dose recommendations in syphilis, including neurosyphilis, are based on very limited data. National or local guidance should be taken into consideration.
Neonates >15 days: The generally recommended doses are 75-100 mg/kg (max 4 g) once daily for 10-14 days. The dose recommendations in syphilis, including neurosyphilis, are based on very limited data. National or local guidance should be taken into consideration.
Ceftriaxone can be administered by intravenous infusion over at least 30 minutes (preferred route) or by slow intravenous injection over 5 minutes. Intravenous intermittent injection should be given over 5 minutes preferably in larger veins.
Intramuscular
50 - 100 mg per kg of body weight
From 50 To 100 mg per kg of body weight once every day
Neonates 0-14 days: The generally recommended dose is 50 mg/kg once daily for 10-14 days. The dose recommendations in syphilis, including neurosyphilis, are based on very limited data. National or local guidance should be taken into consideration.
Neonates >15 days: The generally recommended doses are 75-100 mg/kg (max 4 g) once daily for 10-14 days. The dose recommendations in syphilis, including neurosyphilis, are based on very limited data. National or local guidance should be taken into consideration.
Intramuscular injections should be injected well within the bulk of a relatively large muscle and not more than 1 g should be injected at one site. Dosages greater than 1 g should be divided and injected at more than one site.
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