Active Ingredient: Evinacumab
Evinacumab is indicated as an adjunct to diet and other low-density lipoprotein-cholesterol (LDL-C) lowering therapies for the treatment of adult and paediatric patients aged 5 years and older with homozygous familial hypercholesterolaemia (HoFH).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 15 milligrams evinacumab per kilogram of body weight, once monthly.
The recommended dose is 15 mg/kg administered by intravenous infusion over 60 minutes once monthly (every 4 weeks).
If a dose is missed, it should be administered as soon as possible. Thereafter, treatment with evinacumab should be scheduled monthly from the date of the last dose.
The rate of infusion may be slowed, interrupted or discontinued if the patient develops any signs of adverse reactions, including infusion-associated symptoms.
Evinacumab can be administered without regard to lipoprotein apheresis.
Evinacumab should be administered over 60 minutes by intravenous infusion. Do not administer evinacumab as an intravenous push or bolus.
The rate of infusion may be slowed, interrupted, or discontinued if the patient develops any signs of adverse reactions, including infusion-associated symptoms.
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