Polyneuropathy of hereditary transthyretin-mediated amyloidosis

Active Ingredient: Eplontersen

Indication for Eplontersen

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

45 mg once monthly

For:

Dosage regimens

Subcutaneous, 45 milligrams eplontersen, once monthly.

Detailed description

The recommended dosage is 45 mg administered by subcutaneous injection once monthly.

Missed dose

Administer eplontersen as soon as possible after a missed dose. Resume dosing at monthly intervals from the date of the most recently administered dose.

Dosage considerations

Administer eplontersen as a subcutaneous injection into the abdomen or upper thigh region. The back of the upper arm can also be used as an injection site if a healthcare provider or caregiver administers the injection.

Active ingredient

Eplontersen

Eplontersen is an antisense oligonucleotide-GalNAc conjugate that causes degradation of mutant and wild-type TTR mRNA through binding to the TTR mRNA, which results in a reduction of serum TTR protein and TTR protein deposits in tissues.

Read more about Eplontersen

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