Vulvar and vaginal atrophy in postmenopausal women having moderate to severe symptoms

Active Ingredient: Prasterone

Indication for Prasterone

Population group: women, only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

6.5 mg once daily

For:

Dosage regimens

Vaginal, 6.5 milligrams prasterone, once daily, over the duration of 6 months.

Detailed description

The recommended dose is 6.5 mg prasterone (one pessary) administered once daily, at bedtime.

For the treatment of postmenopausal symptoms, prasterone should only be initiated for symptoms that adversely affect quality of life. In all cases, a careful appraisal of the risks and benefits should be reassessed at least every 6 months and prasterone should only be continued as long as the benefit outweighs the risk.

If a dose is forgotten, it should be taken as soon as the patient remembers. However, if the next dose is due in less than 8 hours, the patient should skip the missed pessary. Two pessaries should not be used to make up for a forgotten dose.

Dosage considerations

The prasterone pessary can be inserted in the vagina with the finger or with an applicator provided within the identified pack.

The pessary should be inserted in the vagina as far as it can comfortably go without force.

Active ingredient

Prasterone

Prasterone, i.e. dehydroepiandrosterone (DHEA), biochemically and biologically identical to the endogenous human DHEA, is a precursor steroid which is inactive by itself and it is converted into oestrogens and androgens. Intrarosa is thus different from the oestrogens preparations since it delivers also androgen metabolites.

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