Active Ingredient: Bevacizumab
Bevacizumab, in addition to platinum-based chemotherapy, is indicated for first-line treatment of adult patients with unresectable advanced, metastatic or recurrent non-small cell lung cancer other than predominantly squamous cell histology.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Intravenous, 7.5 milligrams bevacizumab, once every 3 weeks.
Regimen B: Intravenous, 15 milligrams bevacizumab, once every 3 weeks.
Bevacizumab is administered in addition to platinum-based chemotherapy for up to 6 cycles of treatment followed by bevacizumab as a single agent until disease progression.
The recommended dose of bevacizumab is 7.5 mg/kg or 15 mg/kg of body weight given once every 3 weeks as an intravenous infusion.
Clinical benefit in NSCLC patients has been demonstrated with both 7.5 mg/kg and 15 mg/kg doses. It is recommended that treatment be continued until progression of the underlying disease or until unacceptable toxicity.
It should not be administered as an intravenous push or bolus.
Dose reduction for adverse reactions is not recommended. If indicated, therapy should either be permanently discontinued or temporarily suspended.
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