Active Ingredient: Dupilumab
Dupilumab is indicated for the treatment of moderate-to-severe atopic dermatitis in adults and adolescents 12 years and older who are candidates for systemic therapy.
For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous
200 - 600 mg
From 200 To 600 mg once every 14 day(s)
600 mg
300 mg
The recommended dose of dupilumab for adolescent patients 12 to 17 years of age is specified in the following table.
Dose of dupilumab for subcutaneous administration in adolescent patients 12 years to 17 years of age with atopic dermatitis:
| Body Weight of Patient | Initial Dose | Subsequent Doses (every other week) |
|---|---|---|
| less than 60 kg | 400 mg (two 200 mg injections) | 200 mg |
| 60 kg or more | 600 mg (two 300 mg injections) | 300 mg |
Dupilumab can be used with or without topical corticosteroids. Topical calcineurin inhibitors may be used, but should be reserved for problem areas only, such as the face, neck, intertriginous and genital areas.
Consideration should be given to discontinuing treatment in patients who have shown no response after 16 weeks of treatment for atopic dermatitis. Some patients with initial partial response may subsequently improve with continued treatment beyond 16 weeks. If dupilumab treatment interruption becomes necessary, patients can still be successfully re-treated.
If a dose is missed, administer the dose as soon as possible. Thereafter, resume dosing at the regular scheduled time.
Dupilumab is administered by subcutaneous injection into the thigh or abdomen, except for the 5 cm around the navel.
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