Paroxysmal supraventricular tachycardias, Wolff-Parkinson-White Syndrome

Active Ingredient: Adenine Deoxy Nucleoside

Indication for Adenine Deoxy Nucleoside

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Rapid conversion to a normal sinus rhythm of paroxysmal supraventricular tachycardias, including those associated with accessory by-pass tracts (Wolff-Parkinson-White Syndrome).

For this indication, competent medicine agencies globally authorize below treatments:

first bolus of 0.1 mg/kg, increments of 0.1 mg/kg

Route of admnistration

Intravenous

Defined daily dose

0.1 mg per kg of body weight

Dosage regimen

0.1 mg per kg of body weight once every day

Detailed description

During administration of adenosine cardio-respiratory resuscitation equipment must be available for immediate use if necessary.

The dosing recommended for the treatment of paroxysmal supraventricular tachycardia in the paediatric population is:

  • first bolus of 0.1 mg/kg body weight (maximum dose of 6mg)
  • increments of 0.1 mg/kg body weight as needed to achieve termination of supraventricular tachycardia (maximum dose of 12mg).

Dosage considerations

Adenosine is intended for use with continuous monitoring and ECG recording during administration.

Adenosine should be administered by rapid intravenous (IV) bolus injection into a vein or into an IV line. If given into an IV line it should be injected through as proximally as possible, and followed by a rapid saline flush. If administered through a peripheral vein, a large bore cannula should be used.

Active ingredient

Adenine Deoxy Nucleoside

Adenosine is a purine nucleoside which is present in all cells of the body. Animal pharmacology studies have in several species shown that adenosine has a negative dromotropic effect on the atrioventricular (AV) node.

Read more about Adenine Deoxy Nucleoside

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