Opioid-induced constipation (OIC)

Active Ingredient: Naloxegol

Indication for Naloxegol

Population group: only adults (18 years old or older)

Naloxegol is indicated for the treatment of opioid-induced constipation (OIC) in adult patients who have had an inadequate response to laxative(s).

For this indication, competent medicine agencies globally authorize below treatments:

25 mg once daily

Route of admnistration

Oral

Defined daily dose

25 - 25 mg

Dosage regimen

From 25 To 25 mg once every day

Detailed description

The recommended dose of naloxegol is 25 mg once daily.

When naloxegol therapy is initiated, it is recommended that all currently used maintenance laxative therapy should be halted, until clinical effect of naloxegol is determined.

Dosage considerations

It is recommended that naloxegol is taken in the morning, for patient convenience to avoid bowel movements in the middle of the night.

Naloxegol should be taken on an empty stomach at least 30 minutes prior to the first meal of the day or 2 hours after the first meal of the day.

Active ingredient

Naloxegol

Naloxegol is a PEGylated derivative of the mu-opioid receptor antagonist naloxone. PEGylation reduces naloxegol’s passive permeability and also renders the compound a substrate for the P-glycoprotein transporter. Naloxegol functions as a peripherally-acting mu-opioid receptor antagonist in the gastrointestinal tract, thereby decreasing the constipating effects of opioids without impacting opioid-mediated analgesic effects on the central nervous system.

Read more about Naloxegol

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