Active Ingredient: Pimozide
Pimozide is an antipsychotic of the diphenylbutyl-piperidine series and is indicated in:
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, between 2 milligrams pimozide and 4 milligrams pimozide, once daily at morning, over the duration of 1 week. Afterwards, oral, between 4 milligrams pimozide and 20 milligrams pimozide, once daily at morning. The maximum allowed total dose is 20 milligrams pimozide daily.
Since individual response to antipsychotic drugs is variable, dosage should be individually determined and is best initiated and titrated under close clinical supervision. In determining the initial dose, consideration should be given to the patient’s age, severity of symptoms and previous response to other neuroleptic drugs. Dose increases should be made at weekly intervals or longer, and by increments of 2-4 mg in the daily dose.
The patient should be reviewed regularly to ensure the minimum effective dose is being used.
The dose ranges between 2 and 20 mg daily, with 2 mg as a starting dose. This may be increased according to response and tolerance to achieve an optimum response.
An initial dose of 4 mg daily which may then be gradually increased, if necessary, according to response, to a maximum of 16 mg daily.
For:
Oral, between 1 milligrams pimozide and 2 milligrams pimozide, once daily at morning, over the duration of 1 week. Afterwards, oral, between 2 milligrams pimozide and 10 milligrams pimozide, once daily at morning. The maximum allowed total dose is 10 milligrams pimozide daily.
For:
Oral, between 1 milligrams pimozide and 2 milligrams pimozide, once daily, over the duration of 1 week. Afterwards, oral, between 2 milligrams pimozide and 20 milligrams pimozide, once daily. The maximum allowed total dose is 20 milligrams pimozide daily.
Elderly patients require half the normal starting dose of pimozide.
Since individual response to antipsychotic drugs is variable, dosage should be individually determined and is best initiated and titrated under close clinical supervision.
Dose increases should be made at weekly intervals or longer, and by increments of 2-4 mg in the daily dose.
The patient should be reviewed regularly to ensure the minimum effective dose is being used.
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