Active Ingredient: Maraviroc
Maraviroc, in combination with other antiretroviral medicinal products, is indicated for treatment-experienced adults, adolescents and children of 2 years of age, and older and weighing at least 10 kg infected with only CCR5-tropic HIV-1 detectable.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
300 - 1,200 mg
From 150 To 600 mg 2 time(s) per day every day
The recommended dose of maraviroc should be based on body weight (kg) and should not exceed the recommended adult dose.
The recommended dose of maraviroc differs depending on interactions with concomitant antiretroviral therapy and other medicinal products.
Many medicines have profound effects on maraviroc exposure due to drug-drug interactions. The corresponding paediatric dose can then be obtained from the table below.
Recommended dosing regimen in children aged 2 years and above and weighing at least 10 kg:
| Adult dosage* | Concomitant Medications | Dose of maraviroc in children based on weight | |||
|---|---|---|---|---|---|
| 10 to less than 20 kg | 20 to less than 30 kg | 30 to less than 40 kg | at least 40 kg | ||
| 150 mg twice daily | maraviroc with products that are potent CYP3A inhibitors (with or without a CYP3A inducer) | 50 mg twice daily | 75 mg twice daily | 100 mg twice daily | 150 mg twice daily |
| 300 mg twice daily | maraviroc with products that are not potent CYP3A inhibitors or potent CYP3A inducers | Data to support these doses are lacking. | 300 mg twice daily | 300 mg twice daily | |
| 600 mg twice daily | maraviroc with products that are CYP3A inducers (without a potent CYP3A inhibitor) | Data to support these doses are lacking and maraviroc is not recommended in children taking concomitant interacting medicinal products that in adults would require a 600 mg twice daily dose. | |||
* Based on drug-drug Interactions
Maraviroc can be taken with or without food.
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