Active Ingredient: Ezetimibe
Ezetimibe, co-administered with an HMG-CoA reductase inhibitor (statin) is indicated as adjunctive therapy to diet for use in patients with primary (heterozygous familial and non-familial) hypercholesterolaemia who are not appropriately controlled with a statin alone.
Ezetimibe monotherapy is indicated as adjunctive therapy to diet for use in patients with primary (heterozygous familial and non-familial) hypercholesterolaemia in whom a statin is considered inappropriate or is not tolerated.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 10 milligrams ezetimibe, once daily.
The patient should be on an appropriate lipid lowering diet and should continue on this diet during treatment with ezetimibe.
The recommended dose is 10 mg tablet daily. If as dose is missed, take the missed dose as soon as possible. Do not double the next dose.
When ezetimibe is added to a statin, either the indicated usual initial dose of that particular statin or the already established higher statin dose should be continued. In this setting, the dosage instructions for that particular statin should be consulted.
Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating ezetimibe.
In patients taking a bile acid sequestrant, administer ezetimibe at least 2 hours before or 4 hours after the bile acid sequestrant.
Ezetimibe can be administered at any time of the day, with or without food.
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