NSAID associated benign gastric and duodenal ulcers

Active Ingredient: Esomeprazole

Indication for Esomeprazole

Population group: only adults (18 years old or older)

Healing of gastric ulcers associated with NSAID therapy.

For this indication, competent medicine agencies globally authorize below treatments:

20 mg once daily

Route of admnistration

Oral

Defined daily dose

20 - 20 mg

Dosage regimen

From 20 To 20 mg once every day

Loading dose

20 mg

Detailed description

The usual dose is 20 mg once daily. The treatment duration is 4-8 weeks.

20 mg once daily

Route of admnistration

Intravenous

Defined daily dose

20 - 20 mg

Dosage regimen

From 20 To 20 mg once every day

Detailed description

For healing of gastric ulcers associated with NSAID therapy the usual dose is 20 mg once daily.

Dosage considerations

Injection

20 mg dose: Should be given as an intravenous injection over a period of at least 3 minutes. Any unused solution should be discarded.

Infusion

20 mg dose: Should be given as an intravenous infusion over a period of 10 to 30 minutes. Any unused solution should be discarded.

Active ingredient

Esomeprazole

Esomeprazole is the S-isomer of omeprazole and reduces gastric acid secretion through a specific targeted mechanism of action. Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H+ K+ -ATPase – the acid pump and inhibits both basal and stimulated acid secretion.

Read more about Esomeprazole

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